The studies on indigenous knowledge in the management of typhoid fever and wound infections using leaf extract of Calotropis procera plant were carried out. The leaf were plucked and air dried to a constant weighed pulverize, soaked with four different solvent; aqueous, n.

hexane, ethanol and methanol. Two hundred and fifty gram of the pulverized dried sample was weighed for each solvent extraction and 28.

50±1. 00 (g), 12.

30±1. 00 (g), 16.

40±1. 0 (g) and 22.

60±1. 00(g) with correspondence weigh of fractionated pure isolates of the extract obtained from column chromatography of 13.

00±1. 00, 7.

20±1. 00, 8.

80±1. 00 and 10.

30±1. 00 (ml) was obtained.

The result of phytochemical analysis revealed the highest active components of tannins, saponins, alkaloids, flavonoids, cardiac glycoside and terpenoids in methanolic extracts whereas reducing sugar, phenol, and phlobatannins were absent. Using agar well diffusion methods, the different crude extracts showed visible effect on test organisms compared to the fractionated pure isolates of the extracts and the positive control.

The methanolic extracts were observed to be more potent than other solvent extracts on the test bacteria. .