Выделение и кристаллическая структура физалина B
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4996(2), b = 14. 35620(10), c = 14.
75190(10)Å, V = 2607. 97(5)Å3, Z = 4, Dc = 1.
382 мг/см3, Mr = 542. 56, F(000) = 1152, и μ = 0.
870 мм-1. Итоговое R = 0,0389 и wR = 0,1037 для 47670 наблюдаемых отражений (I > 2ο(I)).
Жесткая молекула состоит из восьми сросшихся колец, включающих два лактона. В симметричном блоке находятся две молекулы C28H32O9, и титульное соединение складывается в трехмерную слоистую структуру посредством водородных связей.
В диапазоне 5-20 мкмоль/л физалин B может значительно ингибировать секрецию воспалительных цитокинов TNF-α и IL-6 на клетках RAW264. 7.
Полученные результаты свидетельствуют о том, что физалин B обладает противовоспалительной активностью in vitro. .
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