Understanding the clinical evolution of Sickle Cell Anaemia: Genetic determinants associated with the clinical evolution of sickle cell anaemia in patients from the state of Pará
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However, vaso-occlusion is a determining factor in clinical evolution, as the endothelium is responsible for vascular homeostasis, and any factor that could upset the balance, such as sickle cell erythrocytes occluding the vessels, triggers a cascade of pathophysiological events. In view of this, our aim was to investigate the influence of genetic polymorphisms that are directly or indirectly involved in vaso-occlusive processes on the clinical variability of sickle cell anaemia.
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£27.18
£28.33 -
£10.58
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