Umbeliprenina e tratamento da leucemia linfocítica crónica (LLC)
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Nas últimas décadas, os medicamentos à base de plantas e os seus constituintes têm atraído a atenção para a quimioterapia da LLC. A umbeliprenina é uma cumarina sesquiterpénica, sintetizada por várias espécies de Ferula.
A indução de apoptose e a citotoxicidade da umbeliprenina para as células cancerosas foram demonstradas pela primeira vez em 2008. Na minha tese de doutoramento, estudei as propriedades da indução de apoptose em linhas celulares CLL pela umbeliprenina.
Pela primeira vez, deveria ter verificado que a umbeliprenina podia induzir a apoptose em linhas celulares de LLC de forma dependente do tempo e da dose. A umbeliprenina e outras cumarinas naturais são compostos esperançosos no futuro da quimioterapia da LLC.
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£27.18
£28.33 -
£10.58
£12.58 -
£16.71
£17.13
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