TWO WAY RELATIONSHIP BETWEEN SYSTEMIC HEALTH AND PERIODONTAL DISEASE: A CLINICIAN'S GUIDE
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A gingival ulceration caused by the inflammatory response may develop around the tooth, allowing intact bacterial cells or their byproducts, such as lipopolysaccharides, pieces of peptidoglycan, and hydrolytic enzymes, to enter the bloodstream. Furthermore, it is understood that the host's defense against periodontal infections includes local production of cytokines, biological mediators including prostaglandins and interleukins, as well as systemic reactions such as the generation of serum antibodies.
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