Volume II documents and analyses genocide and extermination throughout the early modern and modern eras. It tracks their global expansion as European and Asian imperialisms, and Euroamerican settler colonialism, spread across the globe before the Great War, forging new frontiers and impacting Indigenous communities in Europe, Asia, North America, Africa, and Australia.

Twenty-five historians with expertise on specific regions explore examples on five continents, providing comparisons of nine cases of conventional imperialism with nineteen of settler colonialism, and offering a substantial basis for assessing the various factors leading to genocide. This volume also considers cases where genocide did not occur, permitting a global consideration of the role of imperialism and settler-Indigenous relations from the sixteenth to the early twentieth centuries.

It ends with six pre-1918 cases from Australia, China, the Middle East, Africa, and Europe that can be seen as 'premonitions' of the major twentieth-century genocides in Europe and Asia. .