Sur la route des histones au chromosome
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L'ADN doit être disponible pour que le complexe de préinitiation se forme, avec son ARN polymérase et ses facteurs généraux de transcription. Il apparaît que l'ADN enroulé autour des nucléosomes n'est souvent pas accessible pour la formation du complexe de préinitiation, mais qu'il est disponible pour être reconnu par les protéines activatrices de la transcription, également appelées facteurs de transcription spécifiques.
Nous nous concentrons sur les rôles des histones, leur régulation et le remodelage de la chromatine dans l'expression des gènes. .
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