To date, there is no reliable biomarker validated in the exploration of nasopharyngeal cancer (NPC). To assess the value of 2 markers: Cyfra 21-1, a fragment of cytokeratin 19, and β2Microglobulin, a cell membrane protein, in CNP in southern Tunisia, we included 103 individuals: 50 patients with a primary diagnosis of CNP and 53 healthy controls.

CNP patients were classified according to the American Joint Committee on Cancer (AJCC 2010) and the 8th edition TNM (UICC 2017). 40/50 (80%) of CNP patients were positive for at least one of the two markers.

The mean serum level of Cyfra 21-1 was significantly higher in patients than in controls. None of the controls had an elevated level of this marker.

The sensitivity of Cyfra 21-1 in CNP (66%) reached 100% for patients <30 years of age. Cyfra 21-1 levels were significantly correlated with advanced stages (≥III).

Regarding β2M, 56% of patients had an elevated level of the marker. In conclusion, Cyfra 21-1 could be a reliable biomarker for the diagnosis and prognosis of NPC.

Combining this marker with β2M could improve diagnostic sensitivity. .