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Sintesi di pirazolo[1,5-a][1,3,5] triazina e diverse attività biologiche

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Book Details
Language
Italian
Publishers
Edizioni Sapienza (15 Jan. 2024)
Weight
0.09 KG
Publication Date
15/01/2024
ISBN-10
6207041364
Pages
52 pages
ISBN-13
9786207041367
Dimensions
15 x 0.3 x 22 cm
SKU
9786207041367
Author Name
Mazin Najm (Author)
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Le purine possono essere considerate i composti N-eterociclici più ubiquitari e funzionali in natura. Le modifiche strutturali delle purine naturali, in particolare utilizzando sistemi di anelli isosterici, sono state al centro di molti programmi di scoperta di farmaci.

Data la somiglianza strutturale tra l'impalcatura del pirazolo[1,5-a][1,3,5] triazina e il sistema purinico, le modifiche di questa impalcatura hanno dato origine a numerosi agenti bioattivi che potrebbero interagire con i bersagli delle purine biogene. La presente rassegna illustra al meglio le nostre conoscenze sulla sintesi dello scaffold pirazolo[1,5-a][1,3,5]triazina come inibitori enzimatici con valore terapeutico.

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