Sintesi di nuovi analoghi di Capac
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Un nuovo metodo per la preparazione di esteri di acidi formici fosforilati - precursori di nuovi analoghi di Kapah - è stato sviluppato introducendo un terzo reagente di carattere elettrofilo - un estere alchilico cloroalchilante - nel sistema a due componenti "P(III) cloruro + agente decloroalchilante aprotonico";sintesi di un nuovo analogo di "Kapah" - idrazide di acido formico fosforilato. Questi studi hanno dato il via allo studio di una nuova classe di farmaci, le cui azioni farmacologiche, a differenza della maggior parte dei composti organici del fosforo biologicamente attivi, non sono associate alla loro azione anticolinesterasica.
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