Síntese de novos análogos do Capac
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Foi desenvolvido um novo método para a preparação de ésteres de ácidos fórmicos fosforilados - precursores de novos análogos de Kapah - através da introdução de um terceiro reagente de carácter electrofílico - um éster alquil cloroalcoxilante - no sistema de dois componentes "cloreto de P(III) + agente descloroalcoxilante aprónico";síntese de um novo análogo de "Kapah" - hidrazida de ácido fórmico fosforilado. Estes estudos deram início ao estudo de uma nova classe de medicamentos, cujas acções farmacológicas, ao contrário da maioria dos compostos orgânicos fosforados biologicamente activos, não estão associadas à sua ação anticolinesterásica.
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£27.18
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