In modern society, a number of diseases have been on the rise with changing lifestyles or environment influences including diet and psychoemotional stress. Such impact may continue to the development and prevalence of various diseases including Arteriosclerosis, Cancer, Chronic liver disease, Cirrhosis, Chronic Obstructive Pulmonary disease (COPD), Diabetes, Hypertension, Heart diseases, Stroke, Recurrent Aphthous Stomatitis, Asthma, Obesity, Depression and Vascular Dementia.

In an otherwise healthy individual, there are few conditions that develop in the oral mucosa. Recurrent aphthous ulcer (RAU) is the one of most common inflammatory ulcerative condition of the oral mucosa.

The word "aphthous" has been derived from a Greek word "aphtha" which means ulceration. The worldwide prevalence of oral ulcer is 4% out of which 25% are aphthous ulcer, thus becoming the most oral ulcer.

It usually affects the nonkeratinized or poorly keratinized surfaces of the oral mucosa such as labial and buccal mucosa, maxillary and mandibular sulcus, free gingiva, soft palate, floor of mouth and ventral surface of the tongue. They are usually painful, shallow round ulcers with an erythematous halo.

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