PRÉ-ECLAMPSIA EM MULHERES GRÁVIDAS: Frequência e factores: casos de mulheres atendidas no Hospital Protestante MBOUO
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A disfunção placentária é responsável pela libertação na circulação materna de substâncias responsáveis pela disfunção endotelial, caracterizada pela ativação das células endoteliais e pelo aumento da permeabilidade vascular. Parece tratar-se de uma doença em duas fases, com uma fase inicial de síndroma placentária seguida de síndroma materna.
A síndrome materna na pré-eclampsia corresponde a um estado de disfunção endotelial generalizada secundária a um excesso de factores circulantes tóxicos para o endotélio que são libertados pela placenta patológica. A compreensão dos mecanismos que conduzem à isquémia placentária na pré-eclâmpsia deverá esclarecer a patogénese da pré-eclâmpsia.
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