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Un contatto diretto con l'osso osservato istologicamente può essere indicativo della mancanza di una risposta biologica locale o sistemica a quella superficie. Si propone quindi che l'osteointegrazione non sia il risultato di una risposta biologica vantaggiosa del tessuto, ma piuttosto l'assenza di una risposta tissutale negativa.
Il razionale del presente libro è quello di valutare il lavoro scientifico di base svolto sul concetto di biologia dell'osteointegrazione e di discutere i fattori specifici che possono riguardare la guarigione ossea intorno a un impianto. .
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