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As bactérias reproduzem-se dividindo-se em duas, enquanto os vírus se replicam no interior das células hospedeiras. Muitas infeções bacterianas podem ser tratadas com sucesso com antibióticos, mas estes não são úteis contra infeções virais.
A palavra "vírus" vem do latim antigo e significa "lodo" ou "veneno". Paradoxalmente, os primeiros estudos sobre vírus consideravam os filtrados de vírus como um veneno e não como um micróbio, daí o nome vírus.
Em 1898, Friedrichh Loeffler e Paul Frosch encontraram provas de que a causa da febre aftosa no gado era uma partícula infecciosa mais pequena do que qualquer bactéria. Esta foi a primeira pista para a natureza dos vírus, entidades genéticas que se situam algures na zona cinzenta entre o estado vivo e o estado não vivo.
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