Nova via para a síntese de 1,2,4-oxadiazina-5-onas quirais: síntese fácil de novas 1,2,4-oxadiazinas-5-onas quirais a partir de aminoácidos naturais
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Estes reagem depois com cloreto de tionilo seguido de metanol para dar os α-bromoésteres correspondentes. A condensação destes α-bromoésteres previamente preparados com 1-benzenossulfonilpirrolidina-2-carboxamidoxima na presença de dois equivalentes de hidreto de sódio permitiu obter as novas 1,2,4-oxadiazina-5-onas quirais desejadas com bons rendimentos químicos.
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