New route to the synthesis of chiral 1,2,4-oxadiazin-5-ones: easy synthesis of new chiral 1,2,4-oxadiazin-5-ones from natural amino acids
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These will subsequently react with thionyl chloride followed by methanol to give the corresponding α-bromoesters. Condensation of these previously prepared α-bromoesters with 1-benzenesulfonylpyrrolidin-2-carboxamidoxime in the presence of two equivalents of sodium hydride offers desired new chiral 1,2,4-oxadiazin-5-ones in good chemical yields.
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£27.18
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