Nanoparticules d'édaravone: Méthodologie de réponse de la surface
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L'étude de compatibilité entre le médicament et le polymère a été réalisée par spectroscopie FTIR. La morphologie des 17 formulations était sphérique et le potentiel zêta se situait entre -12,7 mV et -28,5 mV.
La taille des particules et l'efficacité du piégeage ont été les principales variables indépendantes dans l'optimisation des formules. La dissolution in vitro de toutes les formulations a été suivie d'une libération initiale en rafale suivie d'une libération soutenue pendant plus de 12 heures.
Sur la base des études de conception factorielle, nous avons optimisé la formulation des nanoparticules d'édaravone. .
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£27.18
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