Nanopartículas de edaravona: Metodologia de resposta à superfície
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O estudo da compatibilidade entre o fármaco e o polímero foi efectuado por espetroscopia FTIR. A morfologia de todas as 17 formulações era esférica e o potencial zeta variava entre -12,7 mV e -28,5 mV.
O tamanho das partículas e a eficiência de aprisionamento foram as principais variáveis independentes na otimização da fórmula. A dissolução in-vitro de todas as formulações foi seguida de uma libertação inicial rápida seguida de uma libertação sustentada durante mais de 12 horas.
Com base nos estudos de design fatorial, optimizámos a formulação da nanopartícula de edaravone. .
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