Наночастицы эдаравона: Методология поверхностного отклика: Metodologiq powerhnostnogo otklika
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Исследование совместимости препарата и полимера проводилось методом ИК-Фурье спектроскопии. Морфология всех 17 препаратов имела сферическую форму, а дзета-потенциал находился в диапазоне от -12,7 мВ до -28,5 мВ.
Размер частиц и эффективность захвата были основной независимой переменной при оптимизации формулы. Растворение in-vitro всех составов сопровождалось первоначальным бурным высвобождением с последующим устойчивым высвобождением в течение более 12 часов.
Основываясь на исследованиях факториального дизайна, мы оптимизировали рецептуру наночастицы эдаравона. .
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