Molecular identification of the CTX-M resistance gene in bacteria: Bacterial resistance
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Its hydrolytic action towards antimicrobials can be interrupted with the use of beta-lactamase inhibitors such as clavulanic acid, sulbactam and tazobactam. The CTX-M gene originated from the mobilisation of beta-lactam resistance genes present in the chromosomes of Kluyvera spp.
bacteria, which from point mutations derived into different subtypes of the gene, in response to the selective pressure intensified by the widespread indiscriminate use of beta-lactam antimicrobials. .
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