MicroRNAs and Telomerase Gene Expression in Alzheimer's Disease: Selected miRNAs and Telomerase Gene Expression Levels as Risk Factors of Alzheimer's Disease
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This study assessed the expression of specific microRNAs (miR-146a-5p and miR-125b-5p) and telomerase genes were taken (human telomerase reverse transcriptase (hTERT) and telomerase RNA component (TERC) as an early, non-invasive, new biomarker for the diagnosis and prediction of Alzheimer's disease. Our findings revealed that alterations in circulating levels of miR-146a-5p and miR-125b-5p might serve as early non-invasive diagnostic markers for the prediction of AD patients.
Also, it shows down-regulation in hTERT and TERC gene expression levels in AD. We propose that telomerase gene expression in circulation can serve as a non-invasive, early, and novel diagnostic marker of AD.
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£27.18
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