Micronúcleos: biomarcador para avaliação do risco de transformação maligna
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Quando estas células se dividem, os fragmentos cromossómicos ficam para trás e são excluídos dos núcleos principais da célula filha. Assim, os micronúcleos contêm material genético que se perdeu do genoma durante a mitose.
Estes fragmentos formam as suas próprias membranas e aparecem como corpos específicos de Feulgen, denominados micronúcleos no citoplasma da célula e são estas células que mais tarde amadurecem e são esfoliadas. Hábitos como o consumo de tabaco e a mastigação de noz de bétele conduzem a esses erros e alterações genéticas como parte do processo de carcinogénese em várias etapas.
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£27.18
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