Microgenómica das lesões odontogénicas: Patologia molecular
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Mecanismos moleculares incertos estão na base do aparecimento destas lesões. De acordo com alguns estudos, os oncogenes ou os genes supressores de tumores podem estar desregulados em determinadas lesões.
Foi documentada uma regulação negativa do gene P53 na AB, DC e OKC. Vários RNAs longos não codificantes, incluindo KIAA0125 e ENST00000512916, também foram desregulados em tecidos AB.
Numerosos genes contêm polimorfismos de nucleótido único que têm sido associados a lesões odontogénicas específicas. Apresentamos um resumo conciso das informações mais recentes sobre o perfil de expressão genética nestas lesões e a relação entre os polimorfismos genéticos e o aparecimento destas lesões.
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£27.18
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