Management of vesiculobullous lesions involves a comprehensive approach tailored to the specific condition and its severity. Accurate diagnosis is crucial and often involves clinical evaluation, biopsy with histopathology, and direct immunofluorescence to identify specific antibodies.

Treatment typically includes pharmacotherapy, including systemic corticosteroids, immunosuppressants, biologics, antibiotics & antivirals that have shown efficacy in certain conditions. Topical treatments, including corticosteroids, are used for localized lesions, alongside proper wound care to prevent infection.

Supportive care focuses on ensuring adequate nutrition, pain management, and patient education about the chronic nature of their condition and the importance of treatment adherence. Regular follow-up is essential to monitor disease activity, adjust treatments, and manage medication side effects.

Effective management requires a multidisciplinary approach involving dermatologists, primary care physicians, and other specialists as needed, to address the various aspects of these complex conditions. .