Just before Sirisha started along with her brother Anirudh and parents Chalapathi and Malathi to the village of her uncle Chidanandam, a beggar Middoo prophesied to her that she would enter into a place which she did not visit for a long time and where an evil power was eagerly waiting for her. The further soothsaying of his was she would be forced to live a life she did not like and she needed to make her dearest people unhappy to escape from that.

As going to her uncle's home was indeed after fifteen years or so and as most people said that Middoo's prophesy hundred percent would come true, she started feeling fear. Making her fear even more her brother Anirudh said to her that an evil goddess Kasakuva would come onto the women of that village and the evil power said by Middoo might be that.

Once entering into that village, she and her brother Anirudh were dumbfounded when they learnt that their parents and uncle's family decided to perform their marriages with their first cousins Jayanth and Ragini. What happened to that brother and sister's lives from then on in that village, how much Middoo's prophesy has come true is the story of the spicy hot romantic thriller 'Lipstick'.