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Questa letteratura discuterà in modo selettivo le cause della clearing delle cellule e le caratteristiche patologiche dei tumori con alterazioni delle cellule chiare, che, a volte, possono rappresentare una sfida e un dilemma diagnostico. Il comportamento biologico può variare da indolente ad aggressivo.
Tuttavia, nella maggior parte dei casi la presenza di tumori a cellule chiare può essere un segno di maggiore aggressività e malignità del tumore. Pertanto, la loro designazione appropriata è fondamentale.
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