The coronavirus disease, 2019 (COVID-19), has led to the worst worldwide healthcare outbreak of the current century. Our knowledge on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus), the agent causing COVID-19, has dramatically increased in recent years.

Further, healthcare systems are facing another outbreak due to COVID-19-long COVID or post-COVID-19 syndrome-which is the presence of long-lasting symptoms after an acute SARS-CoV-2 infection. The development of long-lasting post-COVID-19 symptoms has been called long COVID or a post-COVID-19 condition.

To date, more than 100 potential long-lasting post-COVID symptoms have been potentially attributed to SARS-CoV-2. This Special Issue of Biomedicines, entitled "Latest Research in Post-COVID-19 (long COVID-19): Pathological and Treatment Studies of Sequelae and Complications", has focused on potential gaps in our knowledge regarding the identification, timeframe, mechanisms, and treatment strategies for the management of the post-COVID-19 condition.

The fourteen published papers in this Special Issue cover the following topics: 1, treatment of the post-COVID-19 condition; 2, neonatal repercussion of the SARS-CoV-2 infection; 3, risk factors of severe COVID-19; 4, phenotyping of post-COVID-19 pain; and 5, others. .