In vitro - in vivo Korrelation von Paracetamol und Tramadol bei Kaninchen
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Daher soll eine HPLC-Methode entwickelt und in Plasma validiert werden. Zur Durchführung der invitro - invivo Korrelation werden Formulierungen mit 3 verschiedenen Freisetzungsraten benötigt.
Diese Formulierungen werden in vitro auf ihre Auflösungsrate und in vivo auf ihre Bioverfügbarkeit hin untersucht. Somit wird eine Korrelation hergestellt.
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