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Weltweit gibt es schätzungsweise 300 Millionen Menschen, die als Träger von Hämoglobin S (Hb S) anerkannt sind, einer Erkrankung, die durch den Austausch von Glutaminsäure gegen Valin an Position 6 des β-Globin-Gens auf dem kurzen Arm von Chromosom 11 entsteht und durch die Vererbung eines normalen Hämoglobin-A-Gens von einem Elternteil und eines anormalen mutierten Gens vom anderen Elternteil (AS) gekennzeichnet ist, im Gegensatz zu homozygoten Personen, bei denen beide mutierten Gene vorhanden sind (SS). .
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