Final dissertation: Study of BCR/Abl molecular transcript quantification at diagnosis and follow-up of CML patients
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The main objective of our work is to study the evolution of CML by quantifying the BCR/ABL molecular transcript during the therapeutic phase. This is a retrospective, descriptive study of 30 patients followed in the hematology department of Tizi Ouzou University Hospital, in the consultation unit.
Molecular follow-up showed that 70% of patients achieved MMR with imatinib 400 mg, and 20% of patients who failed imatinib 400 and 600 mg were substituted with a second-generation TKI with 100% MMR. Quantification of the BCR/Abl ratio showed that 96% of patients on imatinib 400mg were cured.
In conclusion, optimizing treatment and using the various TKIs available requires biomolecular monitoring of BCR/Abl transcripts right from diagnosis. .
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£27.18
£28.33 -
£10.58
£12.58 -
£16.71
£17.13
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