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A etiopatogénese é complexa e está principalmente associada à mastigação de noz de Areca, que resulta numa fibrose justaepitelial progressiva dos tecidos moles orais. Manifesta-se por branqueamento e rigidez da mucosa oral, trismo, sensação de ardor na boca, mobilidade reduzida do palato mole e da língua.
O tratamento da fibrose submucosa oral começa com a cessação dos hábitos, continuando depois com suplementos orais como ferro e multivitaminas, seguidos de injeção submucosa local de esteróides e, finalmente, excisão cirúrgica das bandas fibrosas. .
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