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It is also important that we understand the mechanisms regulating their maintenance, expansion and functions for issues relating to safety and efficiency. Finally, in order to improve the therapeutic use of Stem Cells within clinical practice we must characterize the micro-environment in which they exist (e.
g. , hypoxia), their fate and properties.
By including a number of different types of manuscripts in this Special Issue, we have facilitated a discussion about recent fundamental and applied advances that will help the scientific community to develop new therapeutic strategies based on the use of Stem Cells. .
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