ESTADO DA VITAMINA D EM CRIANÇAS ASMÁTICAS
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Foi descrito que a vitamina D tem um efeito imunomodulador através do seu recetor (VDR) e da 1-alfa-hidroxilase, que estão presentes nos linfócitos T e B, nos macrófagos e nas células apresentadoras de antigénios. Desta forma, a 25 hidroxi-vitamina D (25 OH D) reduz a proliferação dos linfócitos T (nomeadamente os linfócitos Thelper-1 [Th1] e Th17) e a produção de certas citocinas "pró-inflamatórias" (nomeadamente Il-2, Il-6 e IFN-γ).
A interação entre a asma e a vitamina D tem sido estudada ao longo das duas últimas décadas. Esta interação ocorre a vários níveis e tem potenciais implicações clínicas para os doentes com asma, afectando a gravidade, o controlo e o prognóstico da doença.
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£27.18
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