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Der Mangel an saurer Sphingomyelinase verbessert die Myelinreparatur

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Book Details
Language
German
Publishers
Verlag Unser Wissen (10 May 2024)
Weight
0.09 KG
Publication Date
10/05/2024
ISBN-10
6207524985
Pages
52 pages
ISBN-13
9786207524983
Dimensions
15 x 0.3 x 22 cm
SKU
9786207524983
Author Name
Marwan Chami (Author)
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In dieser Studie untersuchten wir die Rolle der sauren Sphingomyelinase bei der Demyelinisierung und der Myelinreparatur, indem wir eine akute und chronische Demyelinisierung mit einer 5- oder 12-wöchigen Cuprizon-Behandlung auslösten, gefolgt von einer 2-wöchigen Cuprizon-Entzugsphase, um die Myelinreparatur zu ermöglichen. Unsere Ergebnisse deuten darauf hin, dass die saure Sphingomyelinase eine wichtige Rolle bei der Myelinreparatur spielt und dass ihre Hemmung durch Amitriptylin einen neuen therapeutischen Ansatz für mehrere Patienten darstellen könnte.

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