Comprendre l'évolution clinique de la drépanocytose: Déterminants génétiques associés à l'évolution clinique de la drépanocytose chez des patients de l'État du Pará
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Or, la vaso-occlusion est un facteur déterminant dans l'évolution clinique, car l'endothélium est responsable de l'homéostasie vasculaire, et tout facteur susceptible de rompre cet équilibre, comme l'occlusion des vaisseaux par les érythrocytes drépanocytaires, déclenche une cascade d'événements physiopathologiques. Dans ce contexte, notre objectif était d'étudier l'influence des polymorphismes génétiques directement ou indirectement impliqués dans les processus vaso-occlusifs sur la variabilité clinique de la drépanocytose.
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£27.18
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£10.58
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