Comparison of Analgesic Efficacy of Tramadol and Tapentadol: in Impacted Mandibular Third Molar Surgery: A Prospective Randomized, Double Blind Clinical Study
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This summary compares their analgesic efficacy, side effects, and patient outcomes in managing postoperative pain following this specific surgery. Tramadol, a centrally acting synthetic opioid analgesic, works primarily by binding to the μ-opioid receptor and inhibiting the reuptake of norepinephrine and serotonin.
This dual mechanism contributes to its analgesic effects but also results in a complex side effect profile. Tapentadol, a newer analgesic, also acts on the μ-opioid receptor but with a stronger inhibition of norepinephrine reuptake.
This simplified dual mechanism is hypothesized to offer effective pain relief with a potentially better side effect profile compared to Tramadol. .
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£27.18
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