Biogenesi mitocondriale nella patogenesi dell'endometriosi: Ruolo del numero di copie del DNA mitocondriale nell'endometriosi
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La biogenesi mitocondriale alterata e la risposta infiammatoria indotta dallo stress ossidativo nella cavità pelvica sono state implicate nella patogenesi dell'endometriosi. Essendo una malattia infiammatoria e associata al metabolismo energetico, poiché i geni TFAM, PGC-1α e VDR sono coinvolti nel mantenimento dell'integrità e del numero di copie del DNA mitocondriale, l'analisi dei polimorfismi di TFAM, PGC-1α e VDR in relazione al numero di copie del DNA mitocondriale fornirà spunti per comprendere meglio la fisiopatologia dell'endometriosi.
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£27.18
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