Biogénese mitocondrial na patogénese da endometriose: Papel do número de cópias do ADN mitocondrial na endometriose
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A biogénese mitocondrial deficiente e a resposta inflamatória induzida pelo stress oxidativo na cavidade pélvica têm sido implicadas na patogénese da endometriose. Sendo uma doença inflamatória e associada ao metabolismo energético, uma vez que os genes TFAM, PGC-1α e VDR estão envolvidos na manutenção da integridade e do número de cópias do ADN mitocondrial, a análise dos polimorfismos dos genes TFAM, PGC-1α e VDR em relação ao número de cópias do ADN mitocondrial permitirá compreender melhor a fisiopatologia da endometriose.
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£27.18
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