Auf dem Weg von den Histonen zum Chromosom
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h. es enthält eine Doppelhelix der DNA.
Die um Nukleosomen gewickelte DNA muss für die Bildung des Präinitiationskomplexes mit seiner RNA-Polymerase und allgemeinen Transkriptionsfaktoren zur Verfügung stehen. Es scheint, dass die um Nukleosomen gewickelte DNA für die Bildung des Präinitiationskomplexes oft nicht zugänglich ist, aber für die Erkennung durch transkriptionsaktivierende Proteine, auch spezifische Transkriptionsfaktoren genannt, verfügbar ist.
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