Alterazioni epatiche durante la chemioterapia: Mantenimento della leucemia linfoide acuta
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L'origine di questa malattia è ancora sconosciuta, ma è associata a fattori genetici e ambientali come l'esposizione a radiazioni ionizzanti, agenti chimici e agenti alchilanti. È la malattia maligna più comune nell'infanzia (80% di tutte le leucemie infantili) con un'incidenza annuale di 2-3 casi ogni 100.
000 bambini. L'epatotossicità è una causa frequente di interruzione del trattamento nella fase di mantenimento della leucemia linfoide acuta.
L'interruzione del trattamento aumenta la probabilità di ricaduta ematologica fino al 10%. .
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