Alterações hepáticas durante a quimioterapia: Manutenção da leucemia linfoide aguda
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A origem desta doença é ainda desconhecida, no entanto, está associada a factores genéticos e ambientais, como a exposição a radiações ionizantes, agentes químicos e agentes alquilantes. É a doença maligna mais comum na infância (80% de todas as leucemias em crianças) com uma incidência anual de 2-3 casos por 100 000 crianças.
A hepatotoxicidade é uma causa frequente de interrupção do tratamento na fase de manutenção da leucemia linfoide aguda. Esta interrupção do tratamento aumenta a probabilidade de recidiva hematológica em até 10%.
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